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Ezetimibe may be used alone or with other drugs (such as "statins" or fibrates). 5%) Common ezetimibe side effects when this medicine is used alone may include: Upper respiratory tract infection (4. USES: Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. CLINICAL PHARMACOLOGY Background. Zetia works to reduce the amount of cholesterol your body absorbs. Zetia is a lipid-lowering drug used to lower cholesterol and triglyceride levels in the blood. Concomitant Lipid-Lowering Therapy Zetia may be administered with a statin (in patients with primary hyperlipidemia) or with fenofibrate (in patients with mixed hyperlipidemia) for incremental effect No. The percentages of patients achieving goal LDL-C were similar: 61. 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